My Friend's Little Sister Has It In for Me!

Also known as: Tomodachi no Imouto ga Ore ni dake Uzai / 友達の妹が俺にだけウザい

My Friend's Little Sister Has It In for Me! is a TV series by BLADE that premiered in Fall 2025. It is finished airing with 12 episodes of about 23 minutes each. Genres: Comedy, Romance, Slice of Life. Average AniList score: 6.5/10.

Synopsis

For high schooler Akiteru Ooboshi, the whole youthful experience thing—like fun, friendships, and even having a girlfriend—is a complete waste of time. So when his best friend’s sister, Iroha Kohinata, keeps teasing him, Akiteru naturally finds it annoying. She practically lives in his room, she’s always on his bed, she’s just a raging storm of clinginess! Why is she only annoying around him?!

(Source: Crunchyroll)

My Friend's Little Sister Has It In for Me! episodes

  1. Episode 1: My Friend`s Little Sister Has It in for Me — aired October 4, 2025
  2. Episode 2: The Cousin I Haven`t Seen in Years Is Cold to Me — aired October 11, 2025
  3. Episode 3: Only I Can Be a Pain to My Uncle`s Daughter — aired October 18, 2025
  4. Episode 4: My Friend`s Little Sister Might Be a Delinquent — aired October 25, 2025
  5. Episode 5: My Friend`s Little Sister Keeps Getting Close to Me — aired November 1, 2025
  6. Episode 6: My Friend`s Little Sister Has It in for My Friend`s Enemy — aired November 8, 2025
  7. Episode 7: The Girl Who Confessed to Me Is Cold to Me in Reality — aired November 15, 2025
  8. Episode 8: Everyone I Know Is Being Weird with Me — aired November 22, 2025
  9. Episode 9: My Fake Girlfriend Gets Tough When I Respond to Her Confession — aired November 29, 2025
  10. Episode 10: My Friend`s Little Sister Only Gets an Apology from Me — aired December 6, 2025
  11. Episode 11: We`re Perfect for Training the Drama Club — aired December 13, 2025
  12. Episode 12: My Friend`s Little Sister Really Does Have It in for Me — aired December 20, 2025

Main characters

  • Iroha Kohinata (Main) — voiced by Sayumi Suzushiro
  • Akiteru Ooboshi (Main) — voiced by Haruki Ishiya
  • Mashiro Tsukinomori (Main) — voiced by Tomori Kusunoki
  • Ozuma Kohinata (Supporting) — voiced by Souma Saitou
  • Sumire Kageishi (Supporting) — voiced by Kana Hanazawa
  • Midori Kageishi (Supporting) — voiced by Reina Kondou
  • Otoi (Supporting) — voiced by Azusa Tadokoro
  • Kanaria Kiraboshi (Supporting) — voiced by Yukari Tamura

Anime like My Friend's Little Sister Has It In for Me!

Genres: Comedy, Romance, Slice of Life · Season: Fall 2025